Sebum Regulation & Lipid Barrier Repair with Isorhamnetin from Opuntia Ficus-indica | Randomized Double-Blind Clinical Trial Results

 



 Introduction

The study explores the sebum-regulating, anti-inflammatory, and lipid-restoring efficacy of isorhamnetin extracted from Opuntia ficus-indica through a randomized double-blind clinical trial. As excessive sebum production and chronic inflammation are central to acne and barrier dysfunction, plant-derived flavonoids have emerged as promising therapeutic candidates. This research investigates the translational potential of isorhamnetin as a multifunctional dermatological active ingredient supported by clinical validation.

Phytochemical Profile and Mechanism of Isorhamnetin

Isorhamnetin is a methylated flavonol known for its antioxidant and anti-inflammatory properties. Extracted from Opuntia ficus-indica, it modulates inflammatory cytokines, reduces oxidative stress, and influences sebocyte activity. Mechanistically, it downregulates pro-inflammatory mediators such as IL-6 and TNF-α while enhancing epidermal lipid synthesis pathways, contributing to improved barrier integrity and balanced sebaceous secretion.

 Clinical Trial Design and Methodology

The randomized double-blind clinical trial included controlled participant selection, standardized topical application, and instrumental evaluation of sebum levels, erythema, and lipid parameters. Objective measurements such as sebometry, corneometry, and TEWL analysis ensured quantitative assessment. The double-blind design minimized bias and strengthened the validity of outcomes regarding efficacy and safety.

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