Silk Fibroin and Sericin: Multifunctional Biomaterial Formulations for Advanced Diabetic Wound Healing
Introduction Silk fibroin and sericin are natural proteins obtained from silkworm cocoons and have gained significant attention in biomedical research due to their exceptional biocompatibility and functional versatility. In the context of diabetic wound healing, these proteins address critical challenges such as delayed tissue regeneration, infection susceptibility, and impaired angiogenesis. Their integration into advanced wound formulations represents a promising strategy for improving outcomes in chronic wound management. Biochemical Properties of Silk Fibroin and Sericin Silk fibroin provides strong mechanical stability and controlled biodegradability, while sericin exhibits antioxidant, anti-inflammatory, and antimicrobial properties. Together, they create a synergistic biomaterial system that supports cell adhesion, proliferation, and extracellular matrix formation, which are essential for effective wound healing in diabetic conditions. Multifunctional Formulation...