Hyaluronic Acid Profhilo® Reduces Skin Inflammation & Neuroimmune Changes in Atopic Dermatitis | Breakthrough Mouse Study

 

Pathophysiology of Atopic Dermatitis and Neuroimmune Crosstalk

Atopic dermatitis involves complex immune activation pathways, including elevated Th2 cytokines, mast cell activation, and disrupted skin barrier proteins. Increasing evidence indicates that spinal neuroimmune signaling contributes to chronic itch and inflammatory amplification. Understanding how peripheral skin inflammation influences central nervous system pathways is crucial for developing targeted therapies that address both local and systemic components of the disease.

 Mechanisms of Hyaluronic Acid in Inflammatory Modulation

Hyaluronic acid is a key extracellular matrix component with hydrating, regenerative, and immunomodulatory properties. In inflammatory environments, it influences cytokine signaling, cellular migration, and tissue remodeling. Profhilo®, a stabilized hyaluronic acid complex, may exert anti-inflammatory effects by downregulating pro-inflammatory mediators while enhancing tissue repair pathways, thereby improving both dermal architecture and immune balance.

 Experimental Design in the Mouse Model of Atopic Dermatitis

The study employed a controlled mouse model to simulate atopic dermatitis-like inflammation. Clinical scoring, histological examination, and molecular analyses were used to assess epidermal thickness, immune cell infiltration, and cytokine expression. Additionally, spinal cord tissues were evaluated to examine neuroimmune alterations, providing a comprehensive understanding of both peripheral and central inflammatory modulation following Profiled® administration.


Hyaluronic acid research, Profhilo study, atopic dermatitis mouse model, skin inflammation treatment, neuroimmune modulation, dermatology research, inflammatory skin disease study, cytokine regulation research, bio-remodeling therapy, translational dermatology research,

Nominate now:https://w-i.me/skin
#ResearchAwards #ScienceAwards
#worldresearchawards #AcademicAwards #GlobalResearchAwards

#HyaluronicAcid
#Profhilo
#AtopicDermatitis
#SkinInflammation
#NeuroimmuneResearch
#DermatologyScience

Comments

Post a Comment

Popular posts from this blog

Global Recognition of Skin Diseases as Public Health Priority

Image
The 78th World Health Assembly made history by unanimously adopting the resolution titled ‘Skin diseases as a global public health priority’. This resolution marks shift in recognising skin health as a critical aspect of global public health. The decision reflects years of advocacy and the need for better funding and attention towards skin diseases, particularly in low- and middle-income countries (LMICs). Historical Context The resolution emerged from years of advocacy led by dermatologists and organisations like the International League of Dermatologic Societies (ILDS). Skin diseases affect approximately 1.9 billion people worldwide, yet they have been historically neglected. This resolution aims to change the narrative, denoting skin health as integral to human dignity and social equity. Voices from Low-Resource Settings Experts from regions with limited dermatologic care stress the urgency of this initiative. There is a critical need for increased funding and integration of skin he...
Read more

"Breakthrough in Skincare: Supramolecular Acid-Enzyme Complex for Clearer Skin!"

1. Introduction The pursuit of effective skincare solutions has long driven innovation in dermatological science. In recent years, the development of multifunctional actives targeting key concerns like excess sebum, enlarged pores, and uneven texture has become a research priority. This video introduces a novel supramolecular acid-enzyme complex that merges biochemical precision with skin compatibility to deliver a breakthrough in skin exfoliation and oil regulation. Here, we explore how this formulation was developed, its clinical efficacy, and its potential to redefine skincare standards. 2. Formulation Science Behind the Supramolecular Complex The supramolecular complex integrates hydroxy acids and proteolytic enzymes into a stable, skin-compatible matrix. By leveraging molecular encapsulation techniques, researchers were able to enhance the penetration and sustained release of active compounds while minimizing irritation. This part of the study focused on optimizing the ratio, p...
Read more

Oxygen-Releasing Hydrogels in Biomedicine: Breakthroughs, Benefits & Future Research

  1. Introduction Oxygen-releasing hydrogels are emerging as a revolutionary class of biomaterials with applications across multiple areas of biomedicine. These hydrogels are engineered to provide a sustained release of oxygen, addressing critical challenges in tissue hypoxia, wound healing, and cellular regeneration. Researchers are actively investigating their use for therapeutic purposes, combining materials science, biomedical engineering, and clinical medicine to deliver innovative solutions that improve patient outcomes. 2. Mechanism of Oxygen Release The underlying mechanism of oxygen release in hydrogels involves chemical, enzymatic, or electrochemical pathways that enable controlled oxygen delivery. These systems are designed to mimic physiological oxygen levels, preventing tissue necrosis and supporting healthy cell function. Detailed mechanistic studies focus on the rate of release, stability of oxygen carriers, and compatibility with biological systems to optimize ther...
Read more