How Dietary Protein Influences Psoriasis Inflammation | Experimental Mouse Model Study

 




 Introduction

Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes and dysregulated immune responses. Emerging evidence suggests that dietary factors, particularly protein intake, may modulate inflammatory pathways. This research explores how varying levels of dietary protein influence both cutaneous and systemic inflammation in mice with acute experimental psoriasis, providing insight into the intersection of nutrition, immunology, and dermatological disease mechanisms.

Experimental Design and Methodology

This study utilizes an acute murine psoriasis model to evaluate the impact of controlled dietary protein variations on inflammatory severity. Mice are divided into low-protein, normal-protein, and high-protein diet groups prior to psoriasis induction. Clinical scoring, histopathological analysis, cytokine profiling, and systemic biomarker assessment are performed to determine how protein intake alters inflammatory progression and immune activation patterns.

Cutaneous Inflammatory Response Analysis

The research investigates epidermal thickness, immune cell infiltration, and keratinocyte proliferation in response to dietary protein modulation. Particular focus is placed on pro-inflammatory cytokines such as IL-17, IL-23, and TNF-α. Differences in local skin inflammation provide insights into how macronutrient composition may influence psoriasis severity at the tissue level.

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