Tilapia Skin–Derived Collagen Peptides: Molecular Mechanisms of Anti-Aging Revealed Using Zebrafish Model

 

 Introduction

Skin aging is a complex biological process driven by oxidative stress, collagen degradation, and cellular senescence. Recent research has focused on bioactive peptides derived from natural sources as promising anti-aging agents. Tilapia skin, an abundant marine by-product, offers a sustainable source of collagen peptides with significant biological activity.

Extraction and Identification of Tilapia Skin-Derived Collagen Peptides

This research details the enzymatic hydrolysis and molecular characterization of collagen peptides obtained from tilapia skin. Advanced analytical techniques were used to identify low-molecular-weight peptides with high bioavailability, laying the foundation for their functional evaluation in aging models.

Zebrafish as a Model for Aging Research

The zebrafish aging model provides an efficient and genetically relevant system to study aging-related pathways. Its transparency, rapid life cycle, and conserved molecular mechanisms make it ideal for evaluating the biological effects of collagen peptides on aging and skin physiology.

Molecular Mechanisms Underlying Anti-Aging Effects

Tilapia collagen peptides were shown to modulate key aging-related molecular pathways, including antioxidant defense systems and cellular stress responses. These peptides reduced oxidative damage, improved mitochondrial function, and regulated gene expression associated with longevity.

Impact on Skin Structure and Cellular Integrity

The study demonstrated significant improvements in skin structure, collagen organization, and cellular integrity in peptide-treated zebrafish. These effects indicate enhanced dermal regeneration and delayed onset of aging-related tissue degeneration.

Future Applications in Skincare and Nutraceuticals

The findings support the development of tilapia skin-derived collagen peptides as functional ingredients for anti-aging skincare and nutraceutical products. Their sustainability, safety, and molecular efficacy position them as valuable candidates for next-generation bioactive formulations.

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#CollagenPeptides #TilapiaCollagen #MarineCollagen
#SkinAgingResearch #AntiAgingScience #ZebrafishModel
#MolecularBiology #OxidativeStress #SkinHealth
#BioactivePeptides #AgingMechanisms #DermalResearch
#RegenerativeScience #CosmeceuticalResearch
#NutraceuticalInnovation #ProteinHydrolysates
#SustainableBiomaterials #CellularAging

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