Biosynthesized Lincomycin-Loaded Copper Oxide Nanoparticles Using Cichorium Intybus Thin Film Spray for Advanced Antibacterial and Wound Healing Applications

 1. Introduction

This research focuses on the development of lincomycin-loaded copper oxide nanoparticles (CuO NPs) synthesized through a green biosynthesis method using Cichorium intybus extract. The nanoparticles are integrated into a thin film spray system to enhance antibacterial and wound-healing performance. This eco-friendly approach aligns with the global shift toward sustainable nanotechnology in medical and skincare applications.

2. Green Biosynthesis of Copper Oxide Nanoparticles

The study utilizes Cichorium intybus (commonly known as chicory) extract as a natural reducing and stabilizing agent in the synthesis of copper oxide nanoparticles. The bioactive compounds in the plant enhance the particle stability, minimize toxicity, and promote a controlled morphology suitable for biomedical use. This green synthesis eliminates harsh chemicals and aligns with principles of sustainable chemistry.

3. Drug Loading and Thin Film Fabrication

Lincomycin, an antibiotic effective against Gram-positive bacteria, is encapsulated within the CuO nanoparticles to enhance its delivery and sustained release. The nanoparticles are then incorporated into a thin film spray, providing a uniform coating over wound surfaces. This formulation allows controlled drug diffusion, improved adherence, and protection against microbial invasion.

4. Antibacterial Efficiency and Mechanism of Action

The biosynthesized nanoparticles exhibit enhanced antibacterial activity due to the synergistic effects of copper ions and lincomycin. The study investigates how these particles disrupt bacterial membranes, inhibit protein synthesis, and promote oxidative stress, leading to effective bacterial eradication. The combination of CuO NPs and antibiotics ensures superior performance against resistant strains.

5. Wound Healing Evaluation and Biocompatibility

In vitro and in vivo wound-healing assessments reveal that the CuO-lincomycin thin films significantly accelerate tissue regeneration, collagen deposition, and epithelialization. The biocompatibility of the films ensures minimal cytotoxicity and maximum healing potential. This makes them highly suitable for next-generation wound dressings and medical coatings.

6. Future Prospects and Biomedical Applications

The integration of plant-mediated synthesis, antibiotic loading, and thin film spray technology presents a promising platform for multifunctional biomedical materials. Future studies could explore other bioactive agents, different metal oxides, and scale-up production for clinical applications. This research contributes to the advancement of sustainable nanotechnology in healthcare and wound management systems.

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 #Nanomedicine
 #WoundHealing
 #AntibacterialResearch
 #CopperOxideNanoparticles
 #GreenSynthesis
 #CichoriumIntybus
 #Lincomycin
 #BiomedicalEngineering
 #TissueRegeneration
 #Biomaterials




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