A Reappraisal of Poly-L-Lactic Acid in Facial and Body Aesthetic Indications | Evidence-Based Review
Introduction Poly-L-Lactic Acid (PLLA) represents a significant advancement in regenerative aesthetic medicine, functioning as a biostimulatory agent that induces endogenous collagen synthesis rather than providing immediate volumization alone. This introduction examines the scientific rationale behind PLLA use in facial and body aesthetic indications, emphasizing its mechanism of action, biodegradability, and long-term tissue remodeling capabilities. The reappraisal highlights how evolving clinical evidence has expanded its role beyond traditional facial rejuvenation to comprehensive aesthetic restoration. Mechanism of Action and Collagen Biostimulation PLLA operates through controlled inflammatory stimulation, activating fibroblasts and promoting neocollagenesis over several weeks to months. This topic explores molecular pathways involved in collagen induction, histological changes observed post-injection, and the role of macrophage-mediated tissue remodeling. Unders...